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voltage-dependent Na+ channel
Function:
- mediates voltage-dependent Na+ permeability of excitable membranes
Structure:
- consists of:
a) pore-forming alpha subunit
b) beta-1 subunit
- noncovalently associated with alpha subunit
c) beta-2 subunit
- covalently linked to alpha subunit by disulfide bonds
Interactions
molecular events
General
molecular complex
Na+ channel
phosphoprotein
plasma membrane protein
voltage-gated ion channel
Properties
COMPARTMENT: plasma membrane
MOTIF: ion channel
COMPARTMENT: cellular membrane
MOTIF: membrane region
membrane region
phosphorylation site
ION-PERMEABILITY: Na+
SUBUNITS: Na+ channel protein alpha
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
cytoplasmic loop
LOOP#: 1
cytoplasmic loop
LOOP#: 2
cytoplasmic domain {C-TERMINAL}
Na+ channel protein 1-beta
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
cysteine residue {C21}
MODIFICATION: cysteine residue {C43}
immunoglobulin superfamily domain {22-150}
MOTIF: cysteine residue {C40}
MODIFICATION: cysteine residue {C121}
cysteine residue {C43}
MODIFICATION: cysteine residue {C21}
N-glycosylation site {N93}
N-glycosylation site {N110}
N-glycosylation site {N114}
cysteine residue {C121}
MODIFICATION: cysteine residue {C40}
N-glycosylation site {N135}
transmembrane domain {161-182}
Na+ channel protein 2-beta
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-29}
immunoglobulin superfamily domain {32-154}
MOTIF: N-glycosylation site {N42}
cysteine residue {C55}
MODIFICATION: cysteine residue {C127}
N-glycosylation site {N66}
N-glycosylation site {N74}
cysteine residue {C127}
MODIFICATION: cysteine residue {C55}
transmembrane domain {160-180}
Database Correlations
OMIM correlations
MORBIDMAP 600235
References
- OMIM :accession [600235 182392]
- UniProt :accession O60939
Components
Na+ channel protein, 1-beta subunit (SCN1B)
Na+ channel protein, 2-beta subunit (SCN2B, UNQ326/PRO386)
voltage-dependent Na+ channel protein alpha subunit