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vitamin D binding protein, Gc globulin; group-specific component
Function:
- multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, & urine & on the surface of many cell types
- in plasma, it carries the vitamin D sterols & prevents polymerization of actin by binding its monomers
- VDBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes & with IgG Fc receptor on the membranes of T-lymphocytes
Structure:
- belongs to the ALB/AFP/VDB family
- contains 3 albumin domains
Compartment: secreted
Polymorphism:
- over 80 variants of human DBP have been identified
- most common alleles are called GC*1F, GC*1S, & GC*2
- both total 25-hydroxyvitamin D & vitamin D-binding protein are lower in blacks than in whites
- 25-hydroxyvitamin D:
- 15.6 +/- 0.2 ng/mL vs 25.8 +/- 0.4 ng/mL
- vitamin D-binding protein:
- 168 +/- 3 ug/mL vs 337 +/- 5 ug/mL [4]
General
carrier protein (transporter)
glycoprotein
inter alpha globulin
Properties
SIZE: entity length = 474 aa
MW = 53 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-16}
Albumin 1 {20-202}
MOTIF: cysteine residue {C29}
MODIFICATION: cysteine residue {C75}
cysteine residue {C74}
MODIFICATION: cysteine residue {C83}
cysteine residue {C75}
MODIFICATION: cysteine residue {C29}
cysteine residue {C83}
MODIFICATION: cysteine residue {C74}
cysteine residue {C96}
MODIFICATION: cysteine residue {C112}
cysteine residue {C111}
MODIFICATION: cysteine residue {C122}
cysteine residue {C112}
MODIFICATION: cysteine residue {C96}
cysteine residue {C122}
MODIFICATION: cysteine residue {C111}
cysteine residue {C145}
MODIFICATION: cysteine residue {C190}
cysteine residue {C189}
MODIFICATION: cysteine residue {C198}
cysteine residue {C190}
MODIFICATION: cysteine residue {C145}
cysteine residue {C198}
MODIFICATION: cysteine residue {C189}
Albumin 2 {208-388}
MOTIF: cysteine residue {C220}
MODIFICATION: cysteine residue {C266}
cysteine residue {C265}
MODIFICATION: cysteine residue {C273}
cysteine residue {C266}
MODIFICATION: cysteine residue {C220}
cysteine residue {C273}
MODIFICATION: cysteine residue {C265}
cysteine residue {C286}
MODIFICATION: cysteine residue {C300}
N-glycosylation site {N288}
cysteine residue {C299}
MODIFICATION: cysteine residue {C311}
cysteine residue {C300}
MODIFICATION: cysteine residue {C286}
cysteine residue {C311}
MODIFICATION: cysteine residue {C299}
cysteine residue {C335}
MODIFICATION: cysteine residue {C376}
cysteine residue {C375}
MODIFICATION: cysteine residue {C384}
cysteine residue {C376}
MODIFICATION: cysteine residue {C335}
cysteine residue {C384}
MODIFICATION: cysteine residue {C375}
Albumin 3 {395-474}
MOTIF: cysteine residue {C407}
MODIFICATION: cysteine residue {C453}
cysteine residue {C452}
MODIFICATION: cysteine residue {C462}
cysteine residue {C453}
MODIFICATION: cysteine residue {C407}
cysteine residue {C462}
MODIFICATION: cysteine residue {C452}
MISC-INFO: CONCENTRATION 20-55 MG/DL
Database Correlations
OMIM 139200
UniProt P02774
PFAM correlations
Kegg hsa:2638
References
- UniProt :accession P02774
- OMIM :accession 139200
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 224
- Powe CE et al.
Vitamin D-binding protein and vitamin D status of black
Americans and white Americans.
N Engl J Med 2013 Nov 21; 369:1991
PMID: 24256378
http://www.nejm.org/doi/full/10.1056/NEJMoa1306357