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vitamin A deficiency (hyporetinemia)

Etiology: 1) dietary deficiency 2) disorders interfering with absorption of vitamin A a) celiac disease b) ulcerative colitis c) cystic fibrosis d) liver disease e) intestinal bypass surgery (bariatric surgery) 3) defects in vitamin A synthesis from beta-carotene Genetics: - defects in BCMO1 associated with autosomal dominant hypercarotenemia & vitamin A deficiency Clinical manifestations: 1) xerophthalmia (dry eyes) 2) hyperkeratosis, keratomalacia 3) night blindness 4) xeroderma (dry skin) Laboratory: - serum retinol < 0.20 ug/dL (0.2 mg/L) Management: - severe deficiency: 1) vitamin A 100,000 IU/day for 3 days 2) followed by 50,000 IU daily for 2 weeks 3) then 10,000-20,000 IU daily for 2 months

Related

vitamin A

General

hypovitaminosis (vitamin deficiency)

Database Correlations

OMIM 115300

References

  1. Fiatatone Singh MA & Rosenberg IH, Nutrition and Aging In: Principles of Geriatric Medicine, 4th ed,, Hazzard et al (eds), McGraw-Hill, NY, 1999, pg 81
  2. Rosales SJ et al Relation of serum retinol to acute phase proteins and malarial morbidity in Papua New Guinea children American Journal of Clinical Nutrition, 2000 71(6):1582-1588 PMID: 10837302 http://www.ajcn.org/content/71/6/1582.abstract
  3. OMIM :accession 115300
  4. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015