vinexin; SH3-containing adapter molecule 1; SCAM-1; sorbin & SH3 domain-containing protein 3 (SORBS3, SCAM1)

Function: - vinexin alpha isoform promotes up-regulation of actin stress fiber formation - vinexin beta isoform plays a role in cell spreading & enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain - interacts with DLG5 through its third SH3 domain - interacts with vinculin by the first two SH3 domains & the proline rich region of vinculin - binds to SOS (guanine nucleotide exchange factor of RAS & RAC), through its third SH3 domain; formation of this complex is down-regulated by phosphorylation of SOS - interacts with INPPL1/SHIP2, SAFB2, SOCS7 & SRCIN1 Structure: - contains 3 SH3 domains - contains 1 SoHo domain Compartment: - isoform alpha: - cell junction - cytoplasm, cytoskeleton (putative) - localized at cell-extracellular matrix junctions - isoform beta: - cell junction (putative) - nucleus - cytoplasm, cytoskeleton (putative) - localized at cell-extracellular matrix junctions (putative) - both isoforms localized at focal adhesion & cell-cell adhesion sites Alternative splicing: named isoforms=2; alpha, beta Expression: - both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle & pancreas - isoform beta is especially found in liver

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 671 aa MW = 75 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: SoHo {115-187} Ser phosphorylation site {S217} Thr phosphorylation site {T218} Ser phosphorylation site {S348} Binds to vinculin {380-515} MOTIF: src homology 3 [SH3] domain SITE: 380-439 Ser phosphorylation site {S395} src homology 3 [SH3] domain SITE: 454-515 Thr phosphorylation site {T529} Ser phosphorylation site {S530} Ser phosphorylation site {S545} Ser phosphorylation site {S551} Ser phosphorylation site {S563} src homology 3 [SH3] domain SITE: 612-671 MOTIF: Binds to SOS {612-671}

Database Correlations

OMIM 610795 UniProt O60504 PFAM correlations Entrez Gene 10174

References

Uniprot O60504