selenoprotein S; selS; VCP-interacting membrane protein (SELS, VIMP, AD-015, SBBI8)

Function: - role in the misfolded protein pathway - role in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins - role in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome (ubiquitin-dependent) - probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, & the ATPase complex VCP, which mediates the translocation & ubiquitination - interacts with DERL1 & VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP Structure: belongs to the selenoprotein S family Compartment: - endoplasmic reticulum membrane; single-pass membrane protein

General

membrane protein phosphoprotein selenoprotein

Properties

SIZE: entity length = 189 aa MW = 21 kD COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {28-48} Ser phosphorylation site {S140} selenocysteine residue {C188}

Database Correlations

OMIM 607918 UniProt Q9BQE4 Pfam PF06936 Entrez Gene 55829 Kegg hsa:55829

References

UniProt :accession Q9BQE4