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synaptic vesicular amine transporter; vesicular amine transporter 2; VAT2; monoamine transporter; solute carrier family 18 member 2 (SLC18A2, SVMT, VMAT2)
Function:
- role in the ATP-dependent vesicular transport of biogenic amine neurotransmitters
- pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, & histamine into synaptic vesicles
- requisite for vesicular amine storage prior to secretion via exocytosis
Structure:
- belongs to the major facilitator superfamily vesicular transporter family
Compartment: cytoplasmic vesicle membrane
Pathology:
- VMAT2 (SLC18A2) deficiency found is 8 children of a consanguineous Saudi Arabian family [3]
Pharmacology:
- VMAT2 inhibitor valbenazine (Ingrezza) FDA-approved for treatment of tardive dyskinesia
- deutetrabenazine another VMAT2 inhibitor FDA-approved for treatment of Huntington's chorea
General
glycoprotein
major facilitator superfamily (MFS)
phosphoprotein
solute carrier family 18 (SLC18, SLC18A)
transmembrane 12 protein
Properties
SIZE: entity length = 514 aa
MW = 56 kD
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-20}
transmembrane domain {21-41}
exoplasmic loop {42-129}
MOTIF: N-glycosylation site {N84}
N-glycosylation site {N91}
cysteine residue {C117}
MODIFICATION: cysteine residue {C324}
transmembrane domain {130-150}
cytoplasmic loop {151-159}
transmembrane domain {160-180}
exoplasmic loop {181-189}
transmembrane domain {190-210}
cytoplasmic loop {211-219}
transmembrane domain {220-242}
exoplasmic loop {243-248}
transmembrane domain {249-271}
cytoplasmic loop {272-291}
transmembrane domain {292-311}
exoplasmic loop {312-328}
MOTIF: cysteine residue {C324}
MODIFICATION: cysteine residue {C117}
transmembrane domain {329-352}
cytoplasmic loop {353-357}
transmembrane domain {358-378}
exoplasmic loop {379-389}
transmembrane domain {390-410}
cytoplasmic loop {411-414}
transmembrane domain {415-435}
exoplasmic loop {436-440}
transmembrane domain {441-462}
cytoplasmic domain {463-514}
MOTIF: Ser phosphorylation site {S511}
Ser phosphorylation site {S513}
Database Correlations
OMIM 193001
UniProt Q05940
Pfam PF07690
Kegg hsa:6571
References
- UniProt :accession Q05940
- Wikipedia; Note: vesicular monoamine transporter entry
http://en.wikipedia.org/wiki/vesicular_monoamine_transporter
- Rilstone JJ et al.
Brain dopamine-serotonin vesicular transport disease and its
treatment.
N Engl J Med 2013