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synaptobrevin-3; vesicle-associated membrane protein 3; VAMP-3; cellubrevin; CEB (VAMP3, SYB3)
Function:
- trafficking protein from a constitutively recycling pathway (putative)
- may be involved in a membrane fusion complex
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the synaptobrevin family
- contains 1 v-SNARE coiled-coil homology domain
Compartment:
- membrane, cell junction, synapse, synaptosome
Expression:
- may be present in all cells
General
phosphoprotein
synaptobrevin or vesicle-associated membrane protein (VAMP)
Properties
SIZE: entity length = 100 aa
MW = 11 kD
COMPARTMENT: synaptic vesicle
CELL-REGION: axon terminal
CELL: neuron
WITHIN: brain
MOTIF: SNARE motif {14-74}
MOTIF: Ser phosphorylation site {S58}
transmembrane domain {78-98}
Vesicular {99-100}
Database Correlations
OMIM 603657
UniProt Q15836
Pfam PF00957
Kegg hsa:9341
References
- UniProt :accession Q15836
- McMahon HT, Ushkaryov YA, Edelmann L, Link E, Binz T,
Niemann H, Jahn R, Sudhof TC.
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous
to a putative synaptic vesicle fusion protein.
Nature. 1993 Jul 22;364(6435):346-9.
PMID: 8332193
- Hurtley SM.
Membrane proteins involved in targetted membrane fusion.
Trends Biochem Sci. 1993 Dec;18(12):453-5. Review.
PMID: 8108854