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synaptobrevin-1; vesicle-associated membrane protein 1; VAMP-1; SCN1 protein (VAMP1, SYB1)
Function:
- probably functions in the exocytotic fusion of synaptic vesicles
- role in the targeting &/or fusion of transport vesicles to their target membrane
- interacts with VAPA & VAPB
Structure:
- belongs to the synaptobrevin family
- contains 1 v-SNARE coiled-coil homology domain
Compartment:
1) isoform 1:
a) cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
b) cell junction, synapse, synaptosome
2) isoform 2:
a) cytoplasmic vesicle membrane
3) isoform 3: outer mitochondrial membrane
Alternative splicing: named isoforms=3
Expression: nervous system, skeletal muscle & adipose tissue
Related
SCN1 or synaptobrevin-1 gene
General
phosphoprotein
synaptobrevin or vesicle-associated membrane protein (VAMP)
Properties
SIZE: entity length = 118 aa
MW = 13 kD
COMPARTMENT: mitochondria
cytoplasm
MOTIF: SNARE motif {33-93}
MOTIF: Ser phosphorylation site {S63}
transmembrane domain {97-116}
Vesicular {117-118}
Database Correlations
OMIM 185880
UniProt P23763
Pfam PF00957
Kegg hsa:6843
References
- UniProt :accession P23763
- Sollner T, Whiteheart SW, Brunner M et al
SNAP receptors implicated in vesicle targeting and fusion.
Nature. 1993 Mar 25;362(6418):318-24.
PMID: 8455717