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VDRL reagin slide serum (serum VDRL)

Also see VDRL reagin slide. Indications: - syphilis Clinical significance: - sensitivity: - primary: 77-87% - secondary: 100% - tertiary: 37-94% - false positives: (titers rarely exceed 1:8) a) connective tissue diseases 1] lupus erythematosus 2] rheumatoid arthritis b) infections 1] infectious mononucleosis 2] leprosy 3] malaria 4] Mycoplasma pneumonia c) pregnancy d) addiction e) some immunizations f) advanced age (10% of patients > 70 years of age) - other antibodies found in patients with false + VDRL: a) antinuclear antibodies b) antithyroid antibodies 1] anti-thyroid peroxidase 2] anti-thyroglobulin c) antimitochondrial anatibodies d) rheumatoid factor e) Donath-Landsteiner antibody (paroxysmal cold hemoglobinuria) f) cryoglobulins Management: - a positive VDRL warrants - treponemal serologic test for syphilis

Related

syphilis Venereal Disease Research Laboratory (VDRL)

General

VDRL reagin slide (VDRL)

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1186
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 733, 734, 738
  4. Mini Panel of 2 tests: Treponema pallidum (VDRL) Titer, Serum . Treponema pallidum (VDRL), Serum Laboratory Test Directory ARUP: 93093