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VDRL reagin slide (VDRL)

Principle: - nontreponemal serologic tests used in the diagnosis of syphilis include: - VDRL reagin slide - rapid plasma reagin circle card (RPR) - unheated serum reagin (USR) - toluidine red unheated serum test (TRUST) - all of these tests are based upon detection of immunoglobulin, IgG or IgM (reagin) directed against non treponemal antigens - all nontreponemal assays utilize an active phospholipid (cardiolipin) antigen combined with lecithin & cholesterol in a colloidal particle Clinical significance: - see serum VDRL, CSF VDRL

Related

syphilis Venereal Disease Research Laboratory (VDRL)

Specific

VDRL reagin slide CSF (CSF VDRL) VDRL reagin slide serum (serum VDRL)

General

nontreponemal serologic test for syphilis reagin

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1186
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 733, 734, 738