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vascular cell adhesion protein 1; V-CAM 1; INCAM-100; CD106 (VCAM1, L1CAM)
Function:
- cell-cell recognition
- leukocyte migration/leukocyte-endothelial cell adhesion
- interact with integrins alpha-4/beta-1 (VLA4) on leukocytes
Structure:
- either 1st or the 4th Ig-like C2-type domain is required for VLA4-dependent cell adhesion
- contains 7 Ig-like C2-type domains (immunoglobulin-like)
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2 comment=additional isoforms seem to exist
Expression:
- macrophage-like and dendritic cell types
- inflamed vascular endothelium
- induced by cytokines, including IL-1, TNF-alpha
Pathology:
- may play role in
a) atherosclerosis
b) rheumatoid arthritis
Laboratory:
- vascular cell adhesion molecule 1 in serum/plasma
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 739 aa
MW = 81 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
immunoglobulin superfamily domain {25-105}
MOTIF: cysteine residue {C47}
MODIFICATION: cysteine residue {C95}
cysteine residue {C52}
MODIFICATION: cysteine residue {C99}
cysteine residue {C95}
MODIFICATION: cysteine residue {C47}
cysteine residue {C99}
MODIFICATION: cysteine residue {C52}
immunoglobulin superfamily domain {109-212}
MOTIF: cysteine residue {C137}
MODIFICATION: cysteine residue {C195}
cysteine residue {C195}
MODIFICATION: cysteine residue {C137}
immunoglobulin superfamily domain {223-309}
MOTIF: cysteine residue {C246}
MODIFICATION: cysteine residue {C291}
N-glycosylation site {N273}
cysteine residue {C291}
MODIFICATION: cysteine residue {C246}
immunoglobulin superfamily domain {312-399}
MOTIF: cysteine residue {C335}
MODIFICATION: cysteine residue {C383}
N-glycosylation site {N365}
cysteine residue {C383}
MODIFICATION: cysteine residue {C335}
immunoglobulin superfamily domain {408-506}
MOTIF: N-glycosylation site {N417}
N-glycosylation site {N463}
immunoglobulin superfamily domain {511-595}
MOTIF: N-glycosylation site {N531}
cysteine residue {C534}
MODIFICATION: cysteine residue {C579}
N-glycosylation site {N561}
cysteine residue {C579}
MODIFICATION: cysteine residue {C534}
immunoglobulin superfamily domain {600-684}
transmembrane domain {699-720}
Database Correlations
OMIM 192225
UniProt P19320
PFAM correlations
Entrez Gene 7412
Kegg hsa:7412
References
- UniProt :accession P19320
- Wikipedia; Note: VCAM1 entry
http://en.wikipedia.org/wiki/VCAM1
- SeattleSNPs
http://pga.gs.washington.edu/data/vcam1/
- Functional glycomics gateway - glycan bindingote: VCAM-1
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_266
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005