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vasoactive intestinal polypeptide (VIP); [precursor contains: intestinal peptide PHV-42; intestinal peptide PHM-27; peptide histidine methioninamide 27; vasoactive intestinal peptide]
Function:
- peptide neurotransmitter & hormone involved in appetite & satiety
- causes vasodilation
- lowers arterial blood pressure
- stimulates myocardial contractility
- increases glycogenolysis
- relaxes the smooth muscle of trachea, stomach & gall bladder
Structure:
- belongs to the glucagon family
Compartment:
- secreted
Alternative splicing: named isoforms=2
Pathology:
- VIP is secreted by VIPomas
Related
vasoactive intestinal peptide Ag in tissue
vasoactive intestinal polypeptide [VIP] gene
vasoactive intestinal polypeptide [VIP] receptor
General
gastrointestinal hormone
neurotransmitter
secretin family peptide
Properties
SIZE: entity length = 28 aa
COMPARTMENT: extracellular compartment
SECRETED-BY: epithelial cell
WITHIN: intestine
Database Correlations
OMIM 192320
UniProt P01282
Pfam PF00123
Entrez Gene 7432
Kegg hsa:7432
References
- UniProt :accession P01282
- Wikipedia: vasoactive intestinal peptide
http://en.wikipedia.org/wiki/vasoactive_intestinal_peptide