vesicle-associated membrane protein-associated protein B/C (VAMP-associated protein B/C, VAMP-B/VAMP-C, VAP-B/VAP-C, VAPB)

Function: 1) vesicle trafficking 2) homodimer, & heterodimer with VAPA 3) interacts with VAMP1 & VAMP2 Compartment: plasma membrane, intracellular vesicles Alternative splicing: named isoforms=2 Expression: - ubiquitous - isoform 1 predominates Pathology: - defects in VAPB cause amyotrophic lateral sclerosis 8 (ALS8)

Properties

SIZE: MW = 27 kD entity length = 242 aa COMPARTMENT: cytoplasm MOTIF: MSP {6-123} coiled coil {158-195} Ser phosphorylation site {S205} transmembrane domain {222-242}

Database Correlations

OMIM correlations MORBIDMAP 605704 UniProt O95292 Pfam PF00635

References

UniProt :accession O95292