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Vang-like protein 2 (Van Gogh-like protein 2, strabismus 1, loop-tail protein 1 homolog, VANGL2, KIAA1215, STB1)
Function:
1) involved in the control of early morphogenesis & patterning of both axial midline structures & the development of neural plate
2) role in regulation of planar cell polarity, particularly in orientation of stereociliary bundles in cochlea
3) polarization & movement of myocardializing cells in outflow tract via RHOA
4) interacts through its C-terminal region with the N-terminal half of DVL1, DVL2, DVL3 via PDZ domain of DVL1, DVL2, DVL3
5) interacts with the PDZ domains of SCRIB/SCRB1 & FZD3
Compartment: membrane
General
transmembrane 4 protein
Properties
SIZE: MW = 60 kD
entity length = 521 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-108}
transmembrane domain {109-129}
exoplasmic loop {130-147}
transmembrane domain {148-168}
cytoplasmic loop {169-178}
transmembrane domain {179-199}
exoplasmic loop {200-217}
transmembrane domain {218-238}
cytoplasmic domain {239-521}
Database Correlations
OMIM 600533
UniProt Q9ULK5
Pfam PF06638
References
UniProt :accession Q9ULK5