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synaptobrevin-2; vesicle-associated membrane protein 2; VAMP-2; SCN2 protein (VAMP2, SYB2)

Function: - probably functions in the exocytotic fusion of synaptic vesicles - role in the targeting &/or fusion of transport vesicles to their target membrane - interacts with VAPA & VAPB - synaptobrevin-2 is the proteolytic target of tetanus toxin & botulinum-B toxin Structure: - belongs to the synaptobrevin family - contains 1 v-SNARE coiled-coil homology domain Compartment: - cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane - cell junction, synapse, synaptosome - neuronal synaptic vesicles Expression: nervous system & skeletal muscle

Related

botulinum B toxin (Myobloc) SCN2 or synaptobrevin-2 gene synaptic vesicle tetanus toxin (TeTx); tetanospasmin

General

synaptobrevin or vesicle-associated membrane protein (VAMP)

Properties

SIZE: entity length = 116 aa MW = 13 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl SNARE motif {31-91} MOTIF: Ser phosphorylation site {S75} transmembrane domain {95-114} vesicular {115-116}

Database Correlations

OMIM 185881 UniProt P63027 Pfam PF00957

References

  1. UniProt :accession P63027
  2. Sollner T, Whiteheart SW, Brunner M et al SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993 Mar 25;362(6418):318-24. PMID: 8455717
  3. Barinaga M. Secrets of secretion revealed. Science. 1993 Apr 23;260(5107):487-9. PMID: 8475382