Veterans Affairs Diabetes Trial (VADT)

Study characteristics: - 1791 veterans, mean age 60 years - long-standing diabetes type 2 (mean duration 11.5 years) Groups: - intensive therapy - standard therapy Follow-up: - 5.6 years Results: - mean hemoglobin A1c 6.9% with intensive therapy - mean hemoglobin A1c 8.4% with standard therapy - no differences in outcomes a) death from any cause a) macrovascular complications 1] cardiovascular deaths 2] time to 1st cardiovascular event b) microvascular events 1] retinopathy 2] nephropathy 3] neuropathy - hypoglycemic events more frequent with intensive therapy

References

Duckworth W et al for the VADT Investigators Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360:129 PMID: 19092145 http://dx.doi.org/10.1056/NEJMoa0808431