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vaccinia virus
Closely related to cowpox.
Uses: used in smallpox vaccine (Dryvax)
Epidemiology:
- infection spread by direct contact, not aerosolization
Pathology:
1) causes infections localized to the site of innoculation
2) lesions do contain live vaccinia
3) putative receptor: epidermal growth factor receptor
Clinical manifestations:
1) generally localized to the site of innoculation
2) vesicular or pustular lesions may occur
3) lesions are NOT likely to occur on oral mucosa*
4) encephalitis in severe cases
* distinguishing feature from smallpox
Laboratory:
- vaccinia virus serology
- vaccinia virus DNA
Management:
1) contact isolation
Related
epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1)
Vaccinia virus antibody
General
orthopoxvirus
Properties
KINGDOM: virus
GENOME-TYPE: deoxyribonucleic acid (DNA)
DOUBLE-STRANDED
CIRCULAR
GENOME-SIZE: 130-280 kB
ENVELOPE: PRESENT
CAPSID-SYMMETRY: COMPLEXITY
References
- Harrison's Principles of Internal Medicine, 13th ed.
Isselbacher et al (eds), McGraw-Hill Inc. NY,
1994, pg 769
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- Action Report, Medical Board of California, 85:6 (April)
2003