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vacuolar ATP synthase (v ATPase) or endomembrane proton pump
Function:
- responsible for acidifying a variety of intracellular compartments in eukaryotic cells
Structure:
- heteromultimeric enzyme composed of at least 13 subunits
- peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' & d)
- ATP6V0A1
Related
vacuole
General
adenosine triphosphatase (ATPase)
multisubunit protein
Properties
MOTIF: active site
MOTIF: adenine nucleotide-binding site
SUBUNITS: vacuolar ATP synthase 116 kD subunit a
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
glycosylation site
membrane region
active site
MOTIF: adenine nucleotide-binding site
cytoplasmic domain {C-TERMINAL}
vacuolar ATP synthase catalytic subunit A
MOTIF: active site
MOTIF: adenine nucleotide-binding site
vacuolar ATP synthase subunit B
vacuolar ATP synthase subunit C
vacuolar ATP synthase subunit D
vacuolar ATP synthase subunit E
vacuolar ATP synthase subunit G
vacuolar ATP synthase subunit H
MOTIF: Ser phosphorylation site {S483}
vacuolar ATP synthase 16 kD proteolipid subunit
MOTIF: exoplasmic domain {1-10}
transmembrane domain {11-33}
cytoplasmic loop {34-55}
transmembrane domain {56-76}
exoplasmic loop {77-92}
transmembrane domain {93-114}
cytoplasmic loop {115-126}
transmembrane domain {127-152}
exoplasmic domain {153-155}
V-type proton ATPase 116 kD subunit a isoform 1
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-395}
MOTIF: Thr phosphorylation site {T250}
Tyr phosphorylation site {Y364}
transmembrane domain {396-416}
exoplasmic loop {417-447}
transmembrane domain {448-468}
cytoplasmic loop {469-541}
transmembrane domain {542-562}
exoplasmic loop {563-569}
transmembrane domain {570-590}
cytoplasmic loop {591-607}
transmembrane domain {608-628}
exoplasmic loop {629-637}
transmembrane domain {638-658}
cytoplasmic loop {659-745}
transmembrane domain {746-766}
exoplasmic loop {767-772}
transmembrane domain {773-793}
cytoplasmic domain {794-837}
References
- UniProt :accession P38607
- UniProt :accession P15313
- UniProt :accession Q93050
Components
V-type proton ATPase 116 kD subunit a isoform 1; V-ATPase 116 kD isoform a1; vacuolar proton translocating ATPase 116 kD subunit a isoform 1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kD subunit; vacuolar proton pump subunit 1; vacuolar adenosine triphosphatase subunit Ac116 (ATP6V0A1, ATP6N1, ATP6N1A, VPP1)
vacuolar ATP synthase 16 kD proteolipid subunit; V-type proton ATPase 16 kD proteolipid subunit; V-ATPase 16 kD proteolipid subunit; vacuolar proton pump 16 kD proteolipid subunit (ATP6V0C, ATP6C, ATP6L, ATPL)
vacuolar ATP synthase catalytic subunit A; v-ATPase 69 kD subunit (VPP2)
vacuolar ATP synthase subunit B; endomembrane proton pump 58 kD subunit; v-ATPase B subunit
vacuolar ATP synthase subunit C; v-ATPase C subunit (ATP6V1C)
vacuolar ATP synthase subunit D; ATPase D subunit; V-ATPase D subunit; vacuolar proton pump D subunit; V-ATPase 28 kD accessory protein (ATP6V1D, ATP6M, VATD)
vacuolar ATP synthase subunit E; v-ATPase E subunit (ATP6V1E)
vacuolar ATP synthase subunit G (ATP6G)
vacuolar ATP synthase subunit H; V-ATPase H subunit; vacuolar proton pump H subunit (ATP6V1H)
vacuolar proton translocating ATPase 116 kD subunit a; V-ATPase 116 kD isoform a (ATP6V0A)