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ubiquitin carboxyl-terminal hydrolase FAF-X; deubiquitinating enzyme FAF-X; fat facets in mammals; hFAM; fat facets protein-related, X-linked; ubiquitin thiolesterase FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X (USP9X, DFFRX, FAM, USP9)
Function:
- deubiquitinase involved both in the processing of ubiquitin precursors & of ubiquitinated proteins
- component of TGF-beta/BMP signaling cascade
- regulates chromosome alignment & segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres
- specifically hydrolyzes both Lys-29- & Lys-33-linked polyubiquitins chains
- specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33
- thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
- interacts with SMAD4, MARK4, NUAK1 & BIRC5/survivin
Structure: belongs to the peptidase C19 family
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- widely expressed in embryonic & adult tissues
- escapes X-inactivation
Related
ubiquitin (UBCEP2, UBB, UBC)
General
phosphoprotein
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: entity length = 2570 aa
MW = 292 kD
COMPARTMENT: cytoplasm
MOTIF: Thr phosphorylation site {T590}
cysteine residue {C1566}
Ser phosphorylation site {S1600}
Tyr phosphorylation site {Y1815}
histidine residue {H1879}
Ser phosphorylation site {S2443}
Tyr phosphorylation site {Y2556}
Ser phosphorylation site {S2563}
Database Correlations
OMIM 300072
UniProt Q93008
Pfam PF00443
Entrez Gene 8239
Kegg hsa:8239
ENZYME 3.4.19.12
References
- UniProt :accession Q93008
- OMIM :accession 300072