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sodium (Na+) in urine

Indications: - measurement of urinary Na+ is used to assess volume depletion, acute renal failure, salt-losing nephritis, & in the differential diagnosis of hyponatremia Reference interval: - 25-300 mmol/L (male) - 18-214 mmol/L (female) Clinical significance: - Na+ is freely filtered by the glomerulus; the major route of Na+ excretion is through the kidneys. - renal threshold for sodium is 110-130 mmol/L - nocturnal urinary sodium excretion is 1/5 peak daytime urinary sodium excretion Principle: See sodium (Na+) in body fluid Increases: - increased dietary sodium - adrenal failure - diuretics - alkalosis - diabetes mellitus - Bartter's syndrome - renal tubular acidosis - renal tubulointerstitial disease - SIADH Decreases: - low dietary sodium - poor oral intake - sodium-restricted diet - adrenocortical hyperfunction - prerenal azotemia (volume depletion) - hepatorenal syndrome - abdominal compartment syndrome (case study) [7] Specimen: No special patient preparation is required. Urine: Collect timed or random specimens by standard laboratory procedures. Preservatives are not necessary & may interfere. Refrigerate specimen during collection & keep refrigerated until analysis. Preparation (Urine) 1) Remove Kodak Ektachem Urine Electrolyte Diluent from the refrigerator & allow to reach room temperature (45 minutes). 2) Mix the diluent by gently swirling & inverting the container. DO NOT SHAKE. 3) In a clean, dry container, accurately dilute one part sample with four parts urine diluent (fivefold dilution). Immed- iately cover diluent & return it to refrigerated storage. 4) Thoroughly mix sample with diluent. 5) Analyze the diluted sample & multiply the reported result by 5 to obtain the sodium concentration in the original sample. Minimum sample size 0.5 milliliter: with an optimum size of 1.0 milliliters or larger.

Related

sodium (Na+) in serum

Specific

sodium (Na+) in timed urine

General

urine chemistry test sodium (Na+) in serum & urine

References

  1. Kodak Ektachem 700 Analyzer Operator's Manual, Kodak Clinical Products, Rochester, New York.
  2. Kodak Ektachem Clinical Slide Package Insert, Kodak Clinical Products, Rochester, New York.
  3. Kodak Ektachem Clinical Training Manual, Kodak Clinical Products, Rochester, New York.
  4. Tietz, N. W.: Electrolytes, in Textbook of Clinical Chemistry, Philadelphia, W. B. Saunders Co., p. 1845, 1986.
  5. Clinical Guide to Laboratory Tests, 4th edition, HB Wu ed, WB Saunders, Philadelphia, 2006
  6. Panel of 11 tests Laboratory Test Directory ARUP: 20498 - Panel of 29 tests Laboratory Test Directory ARUP: 20805 - Panel of 8 tests Laboratory Test Directory ARUP: 20851
  7. Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018.

Component-of

electrolytes in urine sodium/creatinine in urine sodium/potassium in urine