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Clara cell phospholipid-binding protein; uteroglobin; CCPBP; Clara cells 10 kD secretory protein; CC10; secretoglobin family 1A member 1; urinary protein 1; UP-1; UP1; urine protein 1 (SCGB1A1, CC10, CCSP, UGB)
Function:
- phospholipase A2 inhibitor
- interacts with fibronectin
- immunoregulatory and/or anti-inflammatory role
- antagonist of neoplastic phenotype
- binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) & weakly progesterone
Structure:
- homodimer; antiparallel disulfide-linked
- belongs to the secretoglobin family
Compartment: secreted
Expression:
- lung: non-ciliated airway epithelial cells
- endometrium - higher in secretory than proliferative phase, expression is regulated by progesterone [5]
- prostate
- gene expression regulated by AP1, OCT & HNF3 transcription factors
Pathology:
- expression is lost during prostate cancer progression, in many lung carcinomas [4] & endometrial carcinoma - (lower levels corresponding to higher grades)
Polymorphism:
- different polymorphisms are associated:
a) asthma
b) pulmonary sarcoidosis
Laboratory:
- Clara cell protein 16 in serum
General
enzyme inhibitor
secretoglobin
Properties
COMPARTMENT: extracellular compartment
SIZE: entity length = 91 aa
MW = 10 kD
MOTIF: signal sequence {1-21}
cysteine residue {C24}
MODIFICATION: cysteine residue {C90}
cysteine residue {C90}
MODIFICATION: cysteine residue {C24}
Database Correlations
OMIM 192020
UniProt P11684
Pfam PF01099
Entrez Gene 7356
Kegg hsa:7356
References
- UniProt :accession P11684
- http://www.gene.ucl.ac.uk/nomenclature/genefamily/scgb.html
- Shijubo N et al
Clinical aspects of Clara cell 10-kDa protein/
uteroglobin (secretoglobin 1A1).
Curr Pharm Des 9(14):1139-49, 2003
PMID: 12769755
- Sjodin A et al
Dysregulated secretoglobin expression in human lung cancers.
Lung Cancer 41(1):49-56, 2003
PMID: 12826312
- Tanaka et al
Expression of uteroglobin in normal and carcinogenic
endometrium and influence of hormone replacement therapy.
Int J Cancer 109:43-8, 2004
PMID: 14735466