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bilirubin in urine (Ictotest)
Normal range: < 0.8 mg/dL
Specimen:
1) urine, fresh, random
2) protect from light
Clinical significance:
- only conjugated bilirubin appears in urine
- unconjugated bilirubin is tightly bound to albumin; it is not filtered by the glomerulus & does not appear in the urine
- conjugated bilirubin may be found in the urine when the serum bilirubin is normal
- resorptive capacity for conjugated bilirubin is low
- bilirubinuria can be early sign of liver disease
- clearance of bilirubin from urine can be early sign of liver recovery
Methods:
1) dipstick (reagent strip)
a) BMC Chemstrig
b) Miles Bili Labstix
c) Ictotest
2) oxidation method (Harrison's sot test of Fouchet's test)
3) limit of detection 0.05 mg/dL
Increases:
1) clinical disorders
- conditions with elevated serum conjugated bilirubin
- intrahepatic & extrahepatic biliary tree obstruction
- hepatocellular injury
- Dubin-Johnson syndrome
- Rotor syndrome
2) pharmaceutical agents
-> chemical interferences:
-> rifampin, chlorpromazine, phenothiazines, phenazopyridine, ethoxazine, etodolac, mefenamic acid, flufenamic acid, salicylate
Related
bilirubin
bilirubin conjugated in serum
General
urine chemistry test
bilirubin in body fluid
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Panel of 22 tests
Laboratory Test Directory ARUP: 20350