protein URG4; HBV X protein up-regulated gene 4 protein; HBxAg up-regulated gene 4 protein (URG4, URGCP, KIAA1507)

Function: - may be involved in cell cycle progression through the regulation of cyclin D1 expression Compartment: - cytoplasm. nucleus - in epithelial cells localized predominantly in the cytoplasm & occasionally in nuclei Alternative splicing: named isoforms=3 Expression: - induced by HBxAg Pathology: - strongly expressed in hepatitis B-infected liver & in hepatocellular carcinoma - highly expressed in well-differentiated gastric cancer tissues & various gastric cancer cell lines - may participate in the development of hepatocellular carcinoma by promoting hepatocellular growth & survival - may play an important role in development of gastric cancer

Properties

GENERAL: uncharacterized protein SIZE: entity length = 931 aa MW = 105 kD COMPARTMENT: cytoplasm cell nucleus FORM: protein URG4

References

UniProt :accession Q8TCY9