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solute carrier family 14 member 2; urea transporter 2; urea transporter, kidney; vasopressin-sensitive urea transporter (SLC14A2, HUT2, UT2)
Function:
- specialized low-affinity vasopressin-regulated urea transporter
- mediates rapid transepithelial urea transport across the inner medullary collecting duct & plays a major role in the urinary concentrating mechanism
- isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane
Structure:
- belongs to the urea transporter family
Compartment:
- apical cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression:
- isoform 1 & isoform 2 are expressed in the inner renal medulla
- isoform 1 is induced by low protein in the diet
- isoform 2 is induced by dehydration
General
glycoprotein
phosphoprotein
solute carrier family 14 (SLC14, SLC14A)
transmembrane 10 protein
Properties
SIZE: entity length = 920 aa
MW = 101 kD
COMPARTMENT: cellular membrane
MOTIF: Ser phosphorylation site {S27}
Ser phosphorylation site {S29}
Ser phosphorylation site {S54}
Ser phosphorylation site {S55}
transmembrane domain {151-170}
transmembrane domain {176-196}
transmembrane domain {204-224}
transmembrane domain {233-253}
transmembrane domain {272-291}
transmembrane domain {302-322}
transmembrane domain {346-366}
transmembrane domain {370-390}
transmembrane domain {392-412}
transmembrane domain {600-620}
transmembrane domain {638-658}
transmembrane domain {666-686}
transmembrane domain {695-715}
N-glycosylation site {N733}
transmembrane domain {764-784}
transmembrane domain {803-823}
transmembrane domain {832-852}
transmembrane domain {854-874}
Database Correlations
OMIM 601611
UniProt Q15849
Pfam PF03253
Entrez Gene 8170
Kegg hsa:8170
References
- UniProt :accession Q15849
- You G et al
Cloning and characterization of the vasopressin-regulated
urea transporter
Nature 365:844 1993
PMID: 8413669