Search
Pennsylvania smell identification scale (UPSIT)
A 40 odor discrimination test.
Self-administered scratch-&-sniff test.
A 10 odor test (subset of 40) predicts development of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). [1]
A 12 odor test (subset of 40): poor performance on odor identification testing correlated with measures of amyloid plaques* & neurofibrillary tangles. [2]
* seems inconsistent with Braak staging
Odors:
- leather, clove, menthol, strawberry, pineapple, natural gas, lemon, lilac, soap, smoke
Impairment of odor discrimation is early event in AD.
One of 5 strong predictors of developing Alzheimer's disease in patients with mild cognitive impairment (MCI).
Related
olfaction & Alzheimer's disease
References
- Tabert MH et al,
A 10-item smell identification scale related to risk for
Alzheimer's disease
Ann Neurol 2005 July;58:155-60
PMID: 15984022
- Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA.
The relationship between cerebral Alzheimer's disease
pathology and odour identification in old age.
J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):30-5.
Epub 2006 Sep 29.
PMID: 17012338
- Growdon ME et al.
Odor identification and Alzheimer disease biomarkers in
clinically normal elderly.
Neurology 2015 May 26; 84:2153.
PMID: 25934852
- Devanand DP et al.
Olfactory identification deficits and increased mortality
in the community.
Ann Neurol 2015 Jun 1;
PMID: 26031760