regulator of nonsense transcripts 3A (nonsense mRNA reducing factor 3A, up-frameshift suppressor homolog 3A, hUpf3, UPF3A, RENT3A, UPF3)

Function: 1) part of a multiprotein post-splicing mRNP complex 2) role in mRNA nuclear export & mRNA surveillance 2) role in nonsense-mediated decay mRNAs containing premature stop codons 3) binds spliced mRNA upstream of exon-exon junctions Compartment: - nucleus, cytoplasm - shuttling between nucleus & cytoplasm Expression: - isoform 1 expressed in testis, uterus, muscle, fetal brain, spinal cord - isoform 2 expressed in fetal brain, spinal cord.

General

phosphoprotein regulator of nonsense transcripts (RENT, nonsense mRNA reducing factor, NORF)

Properties

SIZE: entity length = 476 aa MW = 55 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S68}

Database Correlations

OMIM 605530 UniProt Q9H1J1 Pfam PF03467 Kegg hsa:6511

References

UniProt :accession Q9H1J1