regulator of nonsense transcripts 2 (nonsense mRNA reducing factor 2, up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2)

Function: 1) part of a post-splicing multiprotein complex 2) involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons 3) binds spliced mRNA 4) interacts with RENT1, RENT3, RENT3B, EIF4A1, SUI1 Structure: contains 3 MIF4G domains Compartment: cytoplasm, perinuclear region Alternative splicing: named isoforms=2 Expression: ubiquitous

Properties

SIZE: MW = 148 kD entity length = 1272 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: lysine-rich region {6-136} MOTIF: lysine residue (SEVERAL) coiled coil {54-134} binding site SITE: 94-133 FOR-BINDING-OF: regulator of nonsense transcripts 1 MIF4G 1 {168-431} coiled coil {487-559} MIF4G 2 {569-758} binding site SITE: 711-928 FOR-BINDING-OF: regulator of nonsense transcripts 3A regulator of nonsense transcripts 3B binding site SITE: 757-1272 FOR-BINDING-OF: eukaryotic initiation factor 4A1 eukaryotic translation initiation factor 1 MOTIF: MIF4G 3 {773-986} binding site SITE: 839-859 FOR-BINDING-OF: regulator of nonsense transcripts 3B glutamate-rich region {1025-1094} MOTIF: glutamate residue (SEVERAL) binding site SITE: 1084-1272 FOR-BINDING-OF: regulator of nonsense transcripts 1

Database Correlations

OMIM 605529 UniProt Q9HAU5 PFAM correlations Kegg hsa:2601

References

UniProt :accession Q9HAU5