regulator of nonsense transcripts 1 (nonsense mRNA reducing factor 1, NORF1, up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1)

Function: 1) part of a post-splicing multiprotein complex 2) involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons 3) essential for embryonic viability Structure: - the [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family - belongs to the DNA2/NAM7 helicase family Compartment: cytoplasmic Alternative splicing: named isoforms=2 Expression: ubiquitous

General

phosphoprotein regulator of nonsense transcripts (RENT, nonsense mRNA reducing factor, NORF)

Properties

SIZE: entity length = 1129 aa MW = 124 kD COMPARTMENT: cytoplasm MOTIF: Sufficient for interaction with RENT2 {1-415} MOTIF: proline-rich region SITE: 47-80 MOTIF: proline residue (SEVERAL) Zn finger C2H2-type SITE: 131-159 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 183-213 EFFECTOR-BOUND: Zn+2 ATP-binding site NAME: ATP-binding site SITE: 503-510 serine-rich region {1042-1129} MOTIF: serine residue (SEVERAL) Q motif {1089-1090} Ser phosphorylation site {S1089} Q motif {1107-1108} Ser phosphorylation site {S1107} Ser phosphorylation site {S1127}

Database Correlations

OMIM 601430 UniProt Q92900 Pfam PF04851 Kegg hsa:5976

References

UniProt :accession Q92900