Search
netrin receptor UNC5A (Unc-5 homolog A, Unc-5 homolog 1, UNC5A, UNC5H1, KIAA1976)
Function:
1) receptor for netrin
2) involved in axon guidance
3) mediates axon repulsion of neuronal growth cones in developing nervous system
4) association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion
6) apoptosis induction when NOT associated with netrin
7) interacts with MAGED1 mediated by ZU5 domain
- participates in the induction of apoptosis
8) interacts with PRKCABP,
- regulates its surface expression & leads to its removal from surface of neurons & growth cones
9) phosphorylated on different cytoplasmic Tyr
10) phosphorylated by PKC in vitro
11) phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase (netrin-dependent)
12) proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand
13) cleavage by caspases is required to induce apoptosis
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, kidney
- not expressed in developing or adult lung
Pathology:
- down-regulated in multiple cancers including:
- colorectal cancer
- breast cancer
- ovarian cancer
- uterine cancer
- stomach cancer
- lung cancer
- kidney cancer
Related
netrin
General
glycoprotein
phosphoprotein
UNC5 homolog protein
Properties
SIZE: MW = 93 kD
entity length = 842 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
immunoglobulin superfamily domain {44-141}
MOTIF: cysteine residue {C65}
MODIFICATION: cysteine residue {C124}
N-glycosylation site {N107}
cysteine residue {C124}
MODIFICATION: cysteine residue {C65}
immunoglobulin superfamily domain {155-234}
MOTIF: cysteine residue {C170}
MODIFICATION: cysteine residue {C221}
N-glycosylation site {N218}
cysteine residue {C221}
MODIFICATION: cysteine residue {C170}
TSP TYPE-1 {242-294}
MOTIF: N-glycosylation site {N287}
transmembrane domain {307-327}
proteolytic site {340-341}
ZU5 {439-545}
binding site
SITE: 605-623
FOR-BINDING-OF: netrin receptor DCC
death domain
NAME: death domain
SITE: 761-841
Database Correlations
OMIM 607869
UniProt Q6ZN44
PFAM correlations
Entrez Gene 90249
Kegg hsa:90249
References
- Leonardo ED et al.
Vertebrate homologues of C. elegans UNC-5 are candidate netrin
receptors.
Nature 386:833-8 1997
PMID: 9126742
- UniProt :accession Q6ZN44