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UNC45 homolog A (UNC-45A, Smooth muscle cell-associated protein 1, SMAP-1, UNC45A, SMAP1)
Function:
- may act as co-chaperone for HSP90
- may be necessary for proper folding of myosi
- necessary for normal cell proliferation
- necessary for normal myotube formation & myosin accumulation during muscle cell development
- may play a role in erythropoiesis in stroma cells in spleen
Structure: contains 3 TPR repeats
Alternative splicing: named isoforms=3
Expression:
- detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node & stomach
General
phosphoprotein
Properties
SIZE: MW = 103 kD
entity length = 944 aa
MOTIF: Thr phosphorylation site {T15}
tetratricopeptide repeat {21-54}
tetratricopeptide repeat {58-91}
tetratricopeptide repeat {92-125}
Database Correlations
UniProt Q9H3U1
PFAM correlations
References
UniProt :accession Q9H3U1