Search
ultrasound/microbubble therapy
Mechanism of action:
- nonthermal, noninvasive, focused scanning ultrasound, coupled with intravenously injected microbubbles, stimulates transient openings in the blood brain barrier
- the microbubbles are acoustically activated, expanding and contracting over several cycles, resulting in an opening of endothelial tight junctions & allowing movement across the blood brain barrier
Related
echocardiography bubble study; saline contrast study
General
investigational/experimental therapy
References
- Yager J
Can Noninvasive Ultrasound Plus "Microbubbles" Clean Your
Brain?
NEJM Journal Watch. March 27 2015
Massachusetts Medical Society
(subscription needed) http://www.jwatch.org
- Leinenga G, Gotz J
Scanning ultrasound removes amyloid-beta and restores memory
in an Alzheimer's disease mouse model.
Sci Transl Med 11 March 2015: Vol. 7, Issue 278, p. 278ra33
PMID: 25761889
http://stm.sciencemag.org/content/7/278/278ra33