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UGT1A1 genotyping

Indications: - irinotecan (in doses >150 mg/m2) - history of irinotecan sensitivity - *neutropenia while receiving irinotecan - patient suspected to have Gilbert syndrome - prescription of atazanavir Clinical significance: - 2 decreased function UGT1A1 alleles may be associated with jaundice in patients prescribed atazanavir [3] - neutropenia while receiving irinotecan Laboratory: - see ARUP [1] & ARUP consult [2]

Related

irinotecan; camptothecin (Camptosar, Topotecin, Onivyde, CPT-11) UDP-glucuronosyltransferase-1A (UDPGT-1A, bilirubin-specific isozyme 1, HUG-BR1, UGT1A1, GNT1, UGT1) UDP-glucuronosyltransferase-1A in blood/tissue

Specific

UGT1A1 gene allele 1 UGT1A1 gene allele 2 UGT1A1 gene allele 3 UGT1A1 gene mutation

General

genotyping (allele testing)

References

  1. Panel of 3 tests Laboratory Test Directory ARUP: 51332
  2. ARUP Consult: UGT1A1 Gene Analysis https://arupconsult.com/ati/ugt1a1-gene-analysis
  3. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline information for atazanavir and UGT1A1 https://www.pharmgkb.org/guideline/PA166128738