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mitochondrial uncoupling protein 3; UCP 3 (UCP3 SLC25A9)
Function:
- mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation
- as a result, energy is dissipated in the form of heat
- may play a role in the modulation of tissue respiratory control
- participates in thermogenesis & energy balance
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment: mitochondrial inner membrane
Alternative splicing: named isoforms=3
Expression:
- expressed only in skeletal muscle & heart
- more expressed in glycolytic than in oxidative skeletal muscles
Pathology:
- defects in UCP3 may be involved in severe obesity
General
solute carrier family 25 (SLC25, SLC25A)
uncoupling protein
Properties
SIZE: entity length = 312 aa
MW = 34 kD
COMPARTMENT: mitochondria
MOTIF: Solcar {11-105}
MOTIF: transmembrane domain {11-32}
transmembrane domain {77-99}
Solcar {114-206}
MOTIF: transmembrane domain {120-136}
transmembrane domain {184-200}
Solcar {215-300}
MOTIF: transmembrane domain {218-237}
transmembrane domain {272-294}
Purine nucleotide binding {279-301}
Database Correlations
OMIM correlations
MORBIDMAP 602044
UniProt P55916
Pfam PF00153
Entrez Gene 7352
Kegg hsa:7352
References
- UniProt :accession P55916
- Clapham JC et al
Mice overexpressing human uncoupling protein-3 in skeletal
muscle are hyperphagic and lean.
Nature 406:415, 2000
PMID: 10935638