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mitochondrial uncoupling protein 2; UCP 2; UCPH (UCP2 SLC25A8)
Function:
- mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis
- as a result, energy is dissipated in the form of heat
- acts as a dimer forming a proton channel (putative)
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
- 59% identical to UCP-1
Compartment: mitochondrial inner membrane
Expression:
- widely expressed in adult human tissues, including tissues rich in macrophages
- highest expression in white adipose tissue & skeletal muscle
Polymorphism:
- genetic variation in UCP2 influences susceptibility to obesity
- gene maps to region of chromosome 11 linked to hyperinsulinemia & obesity (body mass index quantitative trait locus type 4) (BMIQ4)
General
solute carrier family 25 (SLC25, SLC25A)
uncoupling protein
Properties
SIZE: entity length = 309 aa
MW = 33 kD
COMPARTMENT: mitochondria
MOTIF: Solcar {11-106}
MOTIF: transmembrane domain {11-32}
transmembrane domain {78-100}
Solcar {114-203}
MOTIF: transmembrane domain {120-136}
transmembrane domain {181-197}
Solcar {212-297}
MOTIF: transmembrane domain {215-234}
transmembrane domain {269-291}
Purine nucleotide binding {276-298}
Database Correlations
OMIM correlations
MORBIDMAP 601693
UniProt P55851
Pfam PF00153
Entrez Gene 7351
Kegg hsa:7351
References
- UniProt :accession P55851
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ucp2/
- Fleury C et al.
Uncoupling protein-2: a novel gene linked to obesity and
hyperinsulinemia.
Nat Genet. 1997 Mar;15(3):269-72.
PMID: 9054939