mitochondrial brown fat uncoupling protein 1; UCP 1; thermogenin (UCP1, SLC25A7)

Function: - mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis - as a result, energy is dissipated in the form of heat - acts as a dimer forming a proton channel Structure: - belongs to the mitochondrial carrier family - contains 3 solcar repeats Compartment: mitochondrial inner membrane Expression: brown adipose tissue Polymorphism: - the Thr-64 polymorphism is associated with an increased waist-to-hip ratio - the Leu-229 polymorphism is associated with susceptibility to diabetes mellitus type 2

General

solute carrier family 25 (SLC25, SLC25A) uncoupling protein

Properties

SIZE: entity length = 307 aa MW = 33 kD COMPARTMENT: mitochondria MOTIF: Solcar {11-102} MOTIF: transmembrane domain {11-32} transmembrane domain {74-96} Solcar {111-201} MOTIF: transmembrane domain {117-133} transmembrane domain {179-195} Solcar {210-295} MOTIF: transmembrane domain {213-232} transmembrane domain {267-289} Purine nucleotide binding {274-296}

Database Correlations

OMIM 113730 UniProt P25874 Pfam PF00153 Entrez Gene 7350 Kegg hsa:7350

References

UniProt :accession P25874