FAS-associated factor 2; UBX domain-containing protein 3B; UBX domain-containing protein 8; protein ETEA (FAF2, ETEA, KIAA0887, UBXD8, UBXN3B)

Function: - may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm & their degradation by the proteasome - identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E & AUP1. interacts with YOD1 Structure: - contains 1 UBA domain - contains 1 UBX domain Compartment: cytoplasm, lipid droplet, endoplasmic reticulum Expression: broadly expressed, with highest levels in brain Pathology: - up-regulated in T-cells & eosinophils from patients with atopic dermatitis

General

phosphoprotein UBX domain-containing protein (UBXD)

Properties

SIZE: entity length = 445 aa MW = 53 kD COMPARTMENT: cytoplasm MOTIF: UBA domain {12-48} Tyr phosphorylation site {Y79} coiled coil {275-350} UBX {357-439}

Database Correlations

UniProt Q96CS3 Pfam PF00789 Entrez Gene 23197 Kegg hsa:23197

References

UniProt :accession Q96CS3