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ubiquilin-2; chap1; DSK2 homolog; protein linking IAP with cytoskeleton 2; PLIC-2; hPLIC-2; ubiquitin-like product chap1/Dsk2 (UBQLN2, N4BP4, PLIC2, HRIHFB2157)
Function:
- increases the t1/2 of proteins destined to be degraded by the proteasome
- colocalizes with proteasome
- interacts with the 19S proteasome subunit
Structure:
- contains 1 UBA domain
- contains 1 ubiquitin-like domain
Compartment:
- cytoplasm, nucleus
- colocalizes with the proteasome
- associated with fibers in mitotic cells
Expression:
- highly expressed in mitotic cells from metaphase to telophase
- expression in non-mitotic cells is very low
General
ubiquilin
Properties
SIZE: entity length = 624 aa
MW = 66 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ubiquitin-like {33-107}
12 X 3 AA tandem repeats of P-X-X {491-526}
MOTIF: consensus repeat {491-493}
consensus repeat {494-496}
consensus repeat {497-499}
consensus repeat {500-502}
consensus repeat {503-505}
consensus repeat {506-508}
consensus repeat {509-511}
consensus repeat {512-514}
consensus repeat {515-517}
consensus repeat {518-520}
consensus repeat {521-523}
consensus repeat {524-526}
UBA domain {581-621}
Database Correlations
OMIM 300264
UniProt Q9UHD9
PFAM correlations
Entrez Gene 29978
Kegg hsa:29978
References
UniProt :accession :Q9UHD9