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small glutamine-rich tetratricopeptide repeat-containing protein A (Vpu-binding protein, UBP, SGTA, SGT)
Function:
1) co-chaperone
2) binds directly to HSC70 & HSP70 & regulates their ATPase activity
Structure:
- contains 3 TPR repeats
Expression: ubiquitous
Pathology:
- interacts with NS1 from parvovirus H-1, with Vpu & Gag from HIV-1
General
phosphoprotein
Properties
SIZE: MW = 34 kD
entity length = 313 aa
MOTIF: Thr phosphorylation site {T81}
tetratricopeptide repeat {91-124}
tetratricopeptide repeat {125-158}
tetratricopeptide repeat {159-192}
glutamine-rich region {275-287}
MOTIF: glutamine residue (SEVERAL)
Thr phosphorylation site {T303}
Ser phosphorylation site {S305}
Database Correlations
OMIM 603419
UniProt O43765
Pfam PF00515
References
UniProt :accession O43765