ubiquitous/mitochondrial creatine kinase (U-mtCK, CKMT1, CKMT1A, CKMT, CKMT1B, Mia-CK)

Function: - reversibly catalyzes transfer of phosphate between ATP & various phosphogens (e.g. creatine phosphate) - creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain & spermatozoa - mitochondrial creatine kinase binds cardiolipin ATP + creatine ADP + phosphocreatine Structure: - octamer composed of four MTCK homodimers - belongs to the ATP:guanido phosphotransferase family Compartment: - mitochondrial inner membrane intermembrane side

Properties

SIZE: entity length = 417 aa MW = 47 kD COMPARTMENT: mitochondrial inner membrane (GO:0005743) MOTIF: binding site SITE: 40-64 FOR-BINDING-OF: cardiolipin Tyr phosphorylation site {Y153} ATP-binding site NAME: ATP-binding site SITE: 161-165 ATP-binding site NAME: ATP-binding site SITE: 224-224 cysteine residue {C316} ATP-binding site NAME: ATP-binding site SITE: 325-325 ATP-binding site NAME: ATP-binding site SITE: 353-358 ATP-binding site NAME: ATP-binding site SITE: 368-368 SUBUNITS: creatine kinase M subunit MOTIF: ATP-binding site NAME: ATP-binding site SITE: 128-132 ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335 creatine kinase B subunit MOTIF: Tyr phosphorylation site {Y39} Tyr phosphorylation site {Y125} ATP-binding site NAME: ATP-binding site SITE: 128-132 Ser phosphorylation site {S164} ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335

Database Correlations

OMIM 123290 UniProt P12532 PFAM correlations KEGG correlations ENZYME 2.7.3.2

References

UniProt :accession P12532

Components

creatine kinase B subunit (CKB) creatine kinase M subunit (CKM)