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ubiquitination

Conjugation of a target protein with ubiquitin. Ubiquitin modifies an epsilon amino group of lysine in the target protein via its C-terminal carboxyl-group. Ubiquitin is covalently attached to target proteins by a multienzymatic system consisting of E1 (ubiquitin-activating), E2 (ubiquitin-conjugating), & E3 (ubiquitin-ligating) enzymes. Poly-ubiquitination generally targets a protein for proteasome- mediated proteolysis, whereas mono-ubiquitination regulates other cellular processes, including: 1) endocytosis [3] 2) alteration of chromatin structure after conjugation of histones [4]

Related

ubiquitin (UBCEP2, UBB, UBC)

General

protein conjugation

References

  1. Gene Ontology Browser (Mouse) GO:0016925 http://www.informatics.jax.org/searches/GO_form.shtml
  2. http://www.biocarta.com/pathfiles/h_sumoPathway.asp
  3. Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: 12506199
  4. Lieberman AP. SUMO, a ubiquitin-like modifier implicated in neurodegeneration. Exp Neurol. 2004 Feb;185(2):204-7. Review. PMID: 14736501