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E3 ubiquitin-protein ligase MYLIP; inducible degrader of the LDL-receptor; Idol; myosin regulatory light chain interacting protein; MIR (MYLIP, BZF1, IDOL, BM-023, PP5242)
Function:
- E3 ubiquitin-protein ligase
- mediates ubiquitination & subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR & LRP8
- proteasomal degradation of MRLC inhibits neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) & reducing CNPY2-stimulated neurite outgrowth
- acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination & subsequent degradation of LDLR
- protein modification; protein ubiquitination
- autoubiquitinated
- interacts with myosin regulatory light chain (MRLC) & TMEM4
Structure:
- the RING domain mediates ubiquitination & the neurite outgrowth inhibitory activity
- contains 1 FERM domain
- contains 1 RING-type Zn+2 finger
Compartment: cytoplasm (probable)
Alternative splicing: named isoforms=2
Expression:
- ubiquitously expressed
- expressed in fetal tissues
- higher expression in placenta & fetal lung
- induced expression is directly activated by NR1H2 & NR1H3
- expression is indirectly induced by LDL
- not sterol-response element-binding protein (SREBP) dependent
General
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 445 aa
MW = 50 kD
COMPARTMENT: cytoplasm
MOTIF: FERM domain
NAME: FERM domain
SITE: 1-279
RING-finger {387-422}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Database Correlations
OMIM 610082
UniProt Q8WY64
PFAM correlations
Entrez Gene 29116
Kegg hsa:29116
References
UniProt :accession Q8WY64