ubiquitin-conjugating enzyme E2 J2; non-canonical ubiquitin-conjugating enzyme 2; NCUBE-2 (UBE2J2, NCUBE2)

Function: - catalyzes the covalent attachment of ubiquitin to other proteins - seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) - protein modification; protein ubiquitination Structure: - belongs to the ubiquitin-conjugating enzyme family Compartment: - endoplasmic reticulum membrane - single-pass type IV membrane protein (putative) Alternative splicing: named isoforms=2

General

membrane protein ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Properties

SIZE: entity length = 259 aa MW = 29 kD COMPARTMENT: endoplasmic reticulum MOTIF: cysteine residue {C94} transmembrane domain {227-247}

Database Correlations

UniProt Q8N2K1 Pfam PF00179 Entrez Gene 118424 Kegg hsa:118424 ENZYME 6.3.2.19

References

UniProt :accession Q8N2K1