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ubiquitin carboxyl-terminal hydrolase 6 (ubiquitin C terminal hydrolase TRE2, ubiquitin thioesterase 6, ubiquitin-specific-processing protease 6, deubiquitinating enzyme 6, proto-oncogene TRE-2, USP6, HRP1, TRE2)
Function:
- ATP-independent isopeptidase activity
- cleaves at the C-terminus of the ubiquitin moiety
- in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity
ubiquitin C-terminal thioester + H2O
ubiquitin + a thiol
Structure:
- belongs to the peptidase C19 family
- contains 1 Rab-GAP TBC domain
Alternative splicing: named isoforms=3
Expression:
- testis specific
- expressed in various cancer cell lines
Pathology: involved in tumorigenesis
Genetics: USP6 gene only exists in the primate lineage
Related
ubiquitin (UBCEP2, UBB, UBC)
General
evolutionary divergent primate protein
testis-specific protein
ubiquitin C-terminal hydrolase; UCH; ubiquitin thiolesterase; ubiquitin-specific processing protease; deubiquitinating enzyme
Properties
SIZE: entity length = 1406 aa
MW = 159 kD
COMPARTMENT: cellular compartment
CELL: unspecified cell type
WITHIN: testis
MOTIF: rab-GAP domain
NAME: rab-GAP domain
SITE: 100-292
cysteine residue {C541}
histidine residue {H1320}
histidine residue {H1328}
Database Correlations
OMIM 604334
UniProt P35125
PFAM correlations
Entrez Gene 9098
Kegg hsa:9098
ENZYME 3.1.2.15
References
- UniProt :accession P35125
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/USP6ID530ch17p13.html