Search
ubiquitin-activating enzyme E1 (ubiquitin-like modifier-activating enzyme 1, A1S9 protein, UBE1, UBA1, A1S9T)
Function:
- catalyzes 1st step of ubiquitin conjugation, ligation of the C-terminal Gly of ubiquitin with Cys within UBE1 (itself), yielding an ubiquitin-E1 thioester & free AMP
- protein degradation; protein ubiquitinylation
Structure:
- monomer (putative)
- belongs to the ubiquitin-activating E1 family
- there are 2 active sites within the E1 molecule, allowing it to accommodate 2 ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site
Related
NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C)
ubiquitin-activating enzyme E1 homolog (ubiquitin-like modifier-activating enzyme 7, UBA7, UBE2, UBE1L)
Specific
ubiquitin-like modifier-activating enzyme 5; ubiquitin-activating enzyme 5; thiFP1; UFM1-activating enzyme; ubiquitin-activating enzyme E1 domain-containing protein 1 (UBA5, UBE1DC1)
General
ligase or synthetase
phosphoprotein
Properties
SIZE: entity length = 1058 aa
MW = 118 kD
MOTIF: Ser phosphorylation site {S46}
Tyr phosphorylation site {Y55}
2 approximate repeats {63-611}
MOTIF: consensus repeat {63-199}
consensus repeat {459-611}
ATP-binding site
NAME: ATP-binding site
SITE: 478-507
cysteine residue {C632}
Database Correlations
OMIM 314370
MORBIDMAP 314370
UniProt P22314
PFAM correlations
Entrez Gene 7317
Kegg hsa:7317
References
- Jentsch et al TIBS 15(May):195 1990
- UniProt :accession P22314