ubiquitin-protein ligase E3C (UBE3C, UBE3C KIAA0010, KIAA10)

Function: 1) E3 ubiquitin-protein ligase 2) may ubiquitinate itself & promote its own degradation 3) interacts with 26S proteasome, CAND2 Structure: - C-terminal is necessary & sufficient for the poly-ubiquitin chain assembly - contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain - contains 1 IQ domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - expressed in skeletal muscle > kidney, pancreas

General

E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein zinc finger protein

Properties

SIZE: entity length = 1083 aa MW = 124 kD COMPARTMENT: cell nucleus MOTIF: domain {1-60} IQ motif {45-74} HECT domain {744-1083} MOTIF: cysteine residue {C1051}

Database Correlations

UniProt Q15386 Pfam PF00632 Entrez Gene 9690 Kegg hsa:9690

References

UniProt :accession Q15386