ubiquitin-conjugating enzyme E2 variant 2; DDvit 1; enterocyte differentiation-associated factor 1; EDAF-1; enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; vitamin D3-inducible protein (UBE2V2, MMS2, UEV2)

Function: - has no ubiquitin ligase activity on its own - UBE2V2/UBE2N heterodimer catalyzes synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 - this type of poly-ubiquitination does not lead to protein degradation by the proteasome - mediates transcriptional activation of target genes - role in control of cell cycle progression & differentiation - role in error-free DNA repair - contributes to survival of cells after DNA damage - heterodimer with UBE2N - binds CHFR Structure: - belongs to the ubiquitin-conjugating enzyme family Expression: - detected in placenta, colon, liver & skin - detected at very low levels in most tissues - up-regulated in cultured fresh blood cells upon treatment with vitamin D3

Properties

SIZE: entity length = 145 aa MW = 16 kD MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl active site MOTIF: cysteine residue

Database Correlations

OMIM 603001 UniProt Q15819 Pfam PF00179 Entrez Gene 7336 Kegg hsa:7336

References

UniProt :accession Q15819