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ubiquitin-conjugating enzyme E2 D2; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kD 2; ubiquitin-protein ligase D2 (UBE2D2, UBC4, UBC5B, UBCH4, UBCH5B)
Function:
- accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
- in vitro catalyzes Lys-48-linked polyubiquitination
- mediates the selective degradation of short-lived & abnormal proteins
- functions in the E6/E6-AP-induced ubiquitination of p53/TP53
- mediates ubiquitination of PEX5 & autoubiquitination of STUB1 & TRAF6
- roles in:
- signal-induced conjugation & subsequent degradation of NFKBIA
- FBXW2-mediated GCM1 ubiquitination & degradation
- MDM2-dependent degradation of p53/TP53
- activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection
- essential for viral activation of IRF3
- protein modification; protein ubiquitination
- interacts with SCF E3 ubiquitin ligase complex & with E3 ubiquitin-protein ligase PJA2
- interacts with PDZRN3 (putative)
- interacts with CNOT4 (via RING domain)
Structure: belongs to the ubiquitin-conjugating enzyme family
General
ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
Properties
SIZE: entity length = 147 aa
MW = 17 kD
MOTIF: active site
MOTIF: cysteine residue
cysteine residue {C85}
Database Correlations
OMIM 602962
UniProt P62837
Pfam PF00179
Entrez Gene 7322
KEGG correlations
ENZYME 6.3.2.19
References
- UniProt :accession P62837
- OMIM :accession 602962