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ubiquitin-conjugating enzyme E2 D1; stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kD 1; ubiquitin-protein ligase D1 (UBE2D1 SFT UBC5A UBCH5 UBCH5A)
Function:
- accepts ubiquitin from the E1 complex & catalyzes its covalent attachment to other proteins
- in vitro catalyzes Lys-48-linked polyubiquitination
- mediates selective degradation of short-lived & abnormal proteins
- role in E6/E6-AP-induced ubiquitination of p53/TP53
- mediates ubiquitination of PEX5 & auto-ubiquitination of STUB1, TRAF6 & TRIM63/MURF1
- ubiquitinates STUB1-associated HSP90AB1 in vitro
- lacks inherent specificity for any particular Lys of ubiquitin
- essential for viral activation of IRF3
- mediates polyubiquitination of CYP3A4
- protein modification; protein ubiquitination
- component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC & TBL1X
- interacts with RNF11
Structure: belongs to the ubiquitin-conjugating enzyme family
Compartment: cytoplasm
Expression: ubiquitous
Pathology:
- up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis
General
ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
Properties
SIZE: entity length = 147 aa
MW = 17 kD
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: cysteine residue
cysteine residue {C85}
Database Correlations
OMIM 602961
UniProt P51668
Pfam PF00179
Entrez Gene 7321
Kegg hsa:7321
ENZYME 6.3.2.19
References
- UniProt :accession P51668
- OMIM :accession 602963
Component-of
some large E3 complex