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ubiquitin-conjugating protein-E2B (ubiquitin-protein ligase B, ubiquitin carrier protein B, E2-17 kD, RAD6B, HR6B, UBE2B)
Function:
- catalyzes covalent attachment of ubiquitin to other proteins
- required for postreplication repair of UV-damaged DNA
- associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on Lys-164
- may be involved in neurite outgrowth
- interacts with RAD18 & UBR2
- protein degradation; protein ubiquitinylation
ATP + ubiquitin + protein lysine
AMP + diphosphate + protein N-ubiquityllysine
Structure: belongs to the ubiquitin-conjugating enzyme family
Compartment:
- cell membrane (putative), nucleus
- in peripheral neurons, expressed both at the plasma membrane & in nuclei (putative)
General
ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
Properties
SIZE: entity length = 152 aa
MW = 17 kD
COMPARTMENT: cell nucleus
MOTIF: cysteine residue {C88}
Database Correlations
OMIM 179095
UniProt P63146
Pfam PF00179
Entrez Gene 7320
Kegg hsa:7320
ENZYME 6.3.2.19
References
- OMIM :accession 179095
- UniProt :accession P63146