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ubiquitin-conjugating protein-E2A (ubiquitin-conjugating enzyme E2-17 kD, RAD6A homolog, HR6A, UBE2A)
Function:
- catalyzes covalent attachment of ubiquitin to other proteins
- required for postreplication repair of UV-damaged DNA
- interacts with RAD18
- protein degradation; protein ubiquitinylation
ATP + ubiquitin + protein lysine
AMP + diphosphate + protein N-ubiquityllysine
Structure:
- belongs to the ubiquitin-conjugating enzyme family
General
ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
Properties
SIZE: entity length = 152 aa
MW = 17 kD
MOTIF: cysteine residue {C88}
Database Correlations
OMIM 312180
MORBIDMAP 312180
UniProt P49459
Pfam PF00179
Entrez Gene 7319
Kegg hsa:7319
ENZYME 6.3.2.19
References
- OMIM :accession 312180
- UniProt :accession P49459